This anomaly is indicative of the larger challenge of culturing various microbial species, referred to as microbial “unculturability.” This cannot be explained by the use of agar alone or by the substitution of an alternative gelling agent, but rather by the difficulties in consistently recreating on an agar plate the multi-variable environment in which microbes grow naturally. Given such challenges, the risk of shortages, and the vulnerabilities of the agar supply chain, why is it so difficult to find suitable alternatives?
The main lesson I learnt from working on these projects is that agents work best when you have approximate knowledge of many things with enough domain expertise to know what should and should not work. Opus 4.5 is good enough to let me finally do side projects where I know precisely what I want but not necessarily how to implement it. These specific projects aren’t the Next Big Thing™ that justifies the existence of an industry taking billions of dollars in venture capital, but they make my life better and since they are open-sourced, hopefully they make someone else’s life better. However, I still wanted to push agents to do more impactful things in an area that might be more worth it.
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2005年，David Duffield和Aneel Bhusri创立了Workday。几年时间，Workday就成为了Oracle和SAP强有力的劲敌。为了帮助公司应对“快速发展的AI时代”，Workday年初将创始人之一的Aneel Bhusri重新拉回CEO职位。这可以说是Workday历史上最关键的转折点之一，希望通过创始人回归来加速AI战略和产品落地。